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Drug Guide

0.9% Sodium Chloride

    0.9% Sodium Chloride

  • Pharmacology
  • Not 'normal' or isotonic - higher sodium (154mmol vs. 140mmol) and chloride (154mmol vs. 105mmol) concentrations than in serum
  • Mostly migrates extravascularly, resulting in oedema
  • Draws fluid out of cells due to hypertonicity

Clinical Use

  • Indications
  • Volume resuscitation for shock
  • Fluid replacement in diabetic ketoacidosis
  • Dehydration
  • Metabolic alkalosis secondary to fluid loss
  • Severe hypercalcaemia
  • Vehicle for intravenous medication administration
  • Contraindications

  • Fluid overload - congestive cardiac failure, severe renal impairment, excessive IV fluids
  • Adverse Effects
  • Fluid overload - electrolyte abnormalities, peripheral oedema, pulmonary oedema
  • Hyperchloraemic metabolic acidosis< (NAGMA)
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