Drug Guide

0.9% Sodium Chloride

    0.9% Sodium Chloride

    • Pharmacology
    • Not ‘normal’ or isotonic - higher sodium (154mmol vs. 140mmol) and chloride (154mmol vs. 105mmol) concentrations than in serum
    • Mostly migrates extravascularly, resulting in oedema
    • Draws fluid out of cells due to hypertonicity

Clinical Use

    • Indications
    • Volume resuscitation for shock
    • Fluid replacement in diabetic ketoacidosis
    • Dehydration
    • Metabolic alkalosis secondary to fluid loss
    • Severe hypercalcaemia
    • Vehicle for intravenous medication administration
    • Contraindications
    • Fluid overload - congestive cardiac failure, severe renal impairment, excessive IV fluids
    • Adverse Effects
    • Fluid overload – electrolyte abnormalities, peripheral oedema, pulmonary oedema
    • Hyperchloraemic metabolic acidosis< (NAGMA)
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