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Tuberculosis
 
 

Respiratory tuberculosis

 
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Overview

  • Tuberculosis is the disease caused by the bacteria Mycobacterium tuberculosis, and may affect almost any organ in the body resulting in a wide range of clinical presentations.

Pathogenesis

    • Risk Factors for Tuberculosis

    • Immunosuppression - HIV, post transplant, autoimmune disease
    • Alcohol abuse
    • Malnutrition
    • Diabetes
    • Smoking

Management

    • Management Options

    • Latent TB

    • Isoniazid
    • Rifampicin
    • Active TB

    • First line (HRZE) - isoniazid, rifampicin, pyrazinamide and ethambutol
    • Other options - amikacin, capreomucin, moxifloxacin, linezolid, cycloserine, clofazimine, meropenem, augmentin
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