Overview
Tuberculosis is the disease caused by the bacteria Mycobacterium tuberculosis, and may affect almost any organ in the body resulting in a wide range of clinical presentations.
Pathogenesis
Risk Factors for Tuberculosis
- Immunosuppression - HIV, post transplant, autoimmune disease
- Alcohol abuse
- Malnutrition
- Diabetes
- Smoking
Management
Management Options
Latent TB
- Isoniazid
- Rifampicin
Active TB
- First line (HRZE) - isoniazid, rifampicin, pyrazinamide and ethambutol
- Other options - amikacin, capreomucin, moxifloxacin, linezolid, cycloserine, clofazimine, meropenem, augmentin
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