MedSchool: Ace Your OSCEsThe Medical Company
GET - On the App Store
Red Cell Disorders

Folate Deficiency Anaemia



Folate, also known as vitamin B9, is an important coenzyme in DNA and amino acid metabolism pathways.


  • Causes of Folate Deficiency

  • Nutritional deficiency - poor intake, alcohol abuse
  • Malabsorption - coeliac disease, inflammatory bowel disease, jejunal resection
  • Increased requirement - pregnancy, malignancy
  • Impaired metabolism - methotrexate, trimethoprim


  • Manifestations of Folate Deficiency

  • Megaloblastic anaemia
  • Neural tube defects (deficiency during pregnancy)
  • Increased cardiovascular risk
  • Dementia


  • Investigations

  • Reduced serum red cell folate levels
  • Macrocytic, hyperchromic anaemia
  • Hypersegmented neutrophils
Next Page
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now

Snapshot: Initialising...