Motor Neuron Disease
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Overview
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- Diagnosis - type of MND, when diagnosed, disease course
- Manifestations - dysphagia, dysarthria, spasticity, weakness
- Management - physiotherapy, respiratory support, optimisation of nutrition, psychological support, pharmacologic agents
- Prognosis - expected trajectory of disease
Clinial Phenotypes of Motor Neuron Disease
- Amyotrophic lateral sclerosis (ALS) - mixed upper and lower motor neuron involvement
- Primary lateral sclerosis - mainly upper motor neuron involvement
- Progressive muscular atrophy - mainly lower motor neuron involvement
- Progressive bulbar palsy - mainly bulbar involvement
Management
Management Options for Motor Neuron Disease
Non-Pharmacologic
- Physiotherapy
- Non-invasive ventilation (NIV)
- Speech pathology assessment
- Consideration of PEG feeding
- Psychological sypport
Pharmacologic
- Rulizole
- Anti-spasmodics - baclofen, diazepam, botox
- Neuropathic agents - pregabalin, amitriptyline
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