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Motor Neuron Disease

 
 
 
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Overview

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    • Diagnosis - type of MND, when diagnosed, disease course
    • Manifestations - dysphagia, dysarthria, spasticity, weakness
    • Management - physiotherapy, respiratory support, optimisation of nutrition, psychological support, pharmacologic agents
    • Prognosis - expected trajectory of disease

    • Clinial Phenotypes of Motor Neuron Disease

    • Amyotrophic lateral sclerosis (ALS) - mixed upper and lower motor neuron involvement
    • Primary lateral sclerosis - mainly upper motor neuron involvement
    • Progressive muscular atrophy - mainly lower motor neuron involvement
    • Progressive bulbar palsy - mainly bulbar involvement

Management

    • Management Options for Motor Neuron Disease

    • Non-Pharmacologic

    • Physiotherapy
    • Non-invasive ventilation (NIV)
    • Speech pathology assessment
    • Consideration of PEG feeding
    • Psychological sypport

    • Pharmacologic

    • Rulizole
    • Anti-spasmodics - baclofen, diazepam, botox
    • Neuropathic agents - pregabalin, amitriptyline
 
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