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Monoclonal Antibodies

 
 
 
Immunotherapy
Haematologic Malignancies
Solid Organ Malignancies
Other
 
 

Anti-RANK-Ligand Antibodies

 
 
  •  
    Subcut
    Denosumab
    Prolia, Xgeva 
     
    Six-monthly injections
    • Mechanism of Action
    • An IgG monoclonal antibody that binds to and inhibits RANK ligand, a cytokine normally responsible for stimulation of osteoclastic maturation and function.

Clinical Use

    • Indications
    • Osteoporosis in men and postmenopausal women
    • Increased risk of fracture due to long-term corticosteroids
    • Bone metastases from solid organ malignancies
    • Hypercalcaemia of malignancy (refractory to bisphosphonates)
    • Adverse Effects
    • Back pain / myalgia / arthralgia
    • Hypertension
    • Dyslipidaemia
    • Rash
 
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