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Monoclonal Antibodies

 
 
 
Immunotherapy
Haematologic Malignancies
Solid Organ Malignancies
Other
 
 

Anti-CD52 Antibodies

 
 
  •  
    IV
    Alemtuzumab
    MabCampath (CLL), LemTrada (MS) 
    • Mechanism of Action
    • A humanized monoclonal antibody that binds to CD-52 receptors found on mature lymphocytes, initiating complement-mediated and antibody-dependent cell-mediated cytotoxicity.

Clinical Use

    • Indications
    • B cell chronic lymphocytic leukaemia (CLL)
    • Relapsing multiple sclerosis (MS)
    • Adverse Effects
    • Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
    • Nausea / vomiting / diarrhoea / anorexia
    • Headache
    • Confusion
    • Hypotension
    • Dyspnoea
    • Arthralgia / myalgia
    • Rash
    • Fatigue
 
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