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Monoclonal Antibodies

 
 
 
Immunotherapy
Haematologic Malignancies
Solid Organ Malignancies
Other
 
 

Anti-CD-20 Antibodies

 
 
  •  
    IV / Subcut
    Rituximab
    Mabthera 
    • Mechanism of Action
    • A monoclonal antibody that targets CD20, a transmembrane protein on the surface of B cells, resulting in antibody-dependent and complement-dependent cytotoxicity.

Clinical Use

    • Indications
    • Chronic lymphocytic leukaemia (CLL)
    • Non-Hodgkin’s lymphoma (NHL)
    • Rheumatoid arthritis
    • Granulomatosis with polyangiitis (GPA)
    • Microscopic polyangiitis (MPA)
    • Adverse Effects
    • Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
    • Injection site reaction
    • Progressive multifocal leukoencephalopathy (PML)
    • Nausea / vomiting
    • Angioedema
 
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