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Neuro Drugs
 
 
 

Sodium Valproate

 
 
  •  
    Oral / IV
    Sodium Valproate
    Epilim, Valpro 

Overview

    • Mechanism of Action

    • Inhibits voltage-gated sodium channels, preventing propagation of action potentials and thus suppressing seizure activity. Also inhibits enzymes that breakdown GABA, resulting in increased GABA-mediated inhibition.
  • Effective against absence seizures due to inhibition of T-type calcium channels in the thalamus.

Clinical Use

    • Indications

    • Generalised seizures
    • Absence seizures
    • Acute mania
    • Maintenance therapy for bipolar disorder
    • Migraine prophylaxis
    • Adverse Effects

    • Nausea / vomiting / diarrhea
    • CNS disturbances – drowsiness, tremor
    • Thrombocytopaenia
    • Alopecia
    • Weight gain
Last updated on January 1st, 2017
 
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The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
 Brodie MJ, Dichter MA. Antiepileptic drugs. N Engl J Med. 1996;334:168–175. Calm DB, Reid JL. Antiparkinsonian drugs: pharmacological and therapeutic aspects. Drugs. 1972 Jul 1;4(1-2):49-74. Cereghino JJ, Biton V, Abou-Khalil B, Dreifuss F, Gauer LJ, Leppik I, et al. Levetiracetam for partial seizures. Results of a double-blind, randomized clinical trial. Neurology 2000;55:236-42 Fenstermacher, N, Levin, M and Ward, T. Pharmacological prevention of migraine. BMJ. 2011; 342: 540-543. Lawrence, ER, Hossain, M and Littlestone, W. Sanomigran for Migraine Prophylaxis; Controlled Multicenter Trial in General Practice. Headache. 1977; 17(3): 109-112.
Macdonald RL, McLean MJ. Anticonvulsant drugs: mechanisms of action. Advances in Neurology. 1986; 44: 713-736.
 Meldrum B, Mechanism of action of valproate. Brain Research Bulletin. 1980; 5(2 Suppl): 579-584. Nutt JG, Woodward WR, Anderson JL. The effect of carbidopa on the pharmacokinetics of intravenously administered levodopa: The mechanism of action in the treatment of parkinsonism. Annals of Neurology. 1985 Nov; 18(5): 537–543. Piercey MF. Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clinical neuropharmacology. 1998 May 1;21(3):141-51. Post RM, Weiss SR, Chuang DM. Mechanisms of action of anticonvulsants in affective disorders: comparisons with lithium. J Clin Psychopharmacol. 1992 Feb;12(1 Suppl): 23S-35S. Rudick RA, Goelz SE. Beta-Interferon for Multiple Sclerosis. Experimental Cell Research. 2011 May; 317(9): 1301-1311. Saxena, PR and Den Boer, MO. Pharmacology of antimigraine drugs. Journal of Neurology. 1991; 238: S28-S35. Tfelt-Hansen P, De Vries P, Saxena PR. Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy. Drugs. 2000 Dec;60(6):1259.
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