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Gastro Drugs
 
 

Antiemetics

Gastric Secretion Modulators

Laxatives

Inflammatory Bowel Disease Medications

 
 

TNF Inhibitors

 
 
  •  
    IV
    Infliximab
    Remicade 
     
    Chimaeric monoclonal antibody to TNF
  •  
    Subcut
    Adalimumab
    Humira 
     
    Human monoclonal antibody to TNF

Overview

    • Mechanism of Action

    • Inhibit tumour necrosis factor alpha (TNF-α), a cytokine involved in systemic inflammation and the acute phase response.

Clinical Use

    • Indications

    • Severe Crohn's disease nonresponsive to other medications
    • Rheumatoid arthritis
    • Seronegative arthritis – psoriatic arthritis, anklyosing spondylitis
    • Psoriasis
    • Adverse Effects

    • Severe infections
    • Reactivation of tuberculosis
    • Anaemia
    • Headache
    • Nausea / diarrhoea
    • Exacerbation of congestive cardiac failure
    • Demyelinating disease
 
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The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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