Login or Register to unlock everything MedSchool has to offer!
Gastro Drugs
 
 

Antiemetics

Gastric Secretion Modulators

Laxatives

Inflammatory Bowel Disease Medications

 
 

Thiopurines

 
 
  •  
    Oral / IV
    Azathioprine
    Imuran 
  •  
    Oral
    6-Mercaptopurine
    Purinethol 

Overview

    • Mechanism of Action

    • Prodrugs that are converted to purine analogues which inhibit purine synthesis, disrupting DNA synthesis and reducing T cell activation.

Clinical Use

    • Indications

    • Inflammatory bowel disease non-responsive to other medications (6-mercaptopurine)
    • Other inflammatory disorders (azathioprine) - rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, vasculitis
    • Prevention of rejection in renal transplantation (azathioprine)
    • Acute leukaemia (6-mercaptopurine)
    • Adverse Effects

    • Bone marrow suppression - anaemia / leukopaenia / thrombocytopaenia
    • Gastrointestinal - nausea / vomiting / diarrhea
    • Hepatotoxicity - elevated LFTs
    • Skin - rash
    • Monitoring

    • Monthly full blood count, renal function and LFTs.
    • Resistance

    • Resistance to thiopurines may occur due to shunting of the 6-MP metabolism pathway to produce excess 6-MMP. Medication changes may be required if resistance develops.
 
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
 

Read More...

The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
Feedback