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Gastro Drugs
 
 
 

Proton Pump Inhibitors

 
 
  •  
    Oral / IV
    Omeprazole
    Losec 
  •  
    Oral / IV
    Esomeprazole
    Nexium 
  •  
    Oral / IV
    Pantoprazole
    Somac 
  •  
    Oral
    Rabeprazole
    Pariet 

Overview

    • Mechanism of Action

    • Inhibit H⁺ / K⁺ ATPase, the channel responsible for pumping gastric acid into the lumen.
    • Pharmacology

    • Prodrugs that require gastric acid in order to be activated.

Clinical Use

    • Indications

    • Gastro-oesophageal reflux disease
    • Peptic ulceration
    • Zollinger-Ellison syndrome
    • Adverse Effects

    • Headache
    • Nausea / vomiting / diarrhea
    • Hypomagnesaemia
  • There is no evidence that long-term PPI use has a clinically significant effect on the absorption of nutrients.
Last updated on January 1st, 2017
 
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