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Gastro Drugs
 
 

Antiemetics

Gastric Secretion Modulators

Laxatives

Inflammatory Bowel Disease Medications

 
 

Osmotic Laxatives

 
 
  •  
    Oral
    Magnesium Sulphate
    Epsom Salt 
  •  
    Oral
    Macrogol 3350
    Movicol, Glycoprep, Osmolax 
     
    Iso-osmotic with the gut, preventing water and electrolyte loss
  •  
    Oral
    Lactulose
    Actilax 
     
    Also used for treatment of hepatic encephalopathy – metabolized by bacteria into D-lactate, reducing gut pH and preventing absorption of ammonia
  •  
    Oral / Rectal
    Sorbitol
    Microlax enema 

Overview

    • Mechanism of Action

    • Osmotically active agents that draw water into the lumen of the gut.

Clinical Use

    • Indications

    • Constipation
    • Bowel preparation prior to procedures such as colonoscopy (macrogol 3350)
    • Hepatic encephalopathy (lactulose)
    • Adverse Effects

    • Flatulence / diarrhea
    • Nausea / vomiting
    • Electrolyte disturbances
 
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The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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