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Gastro Drugs


Gastric Secretion Modulators


Inflammatory Bowel Disease Medications



    Oral / IV
    Weekly dosing


    • Mechanism of Action

    • Inflammatory diseases: inhibits interleukin-1 and interleukin 6 activity, and altering the numbers of different lymphocyte subsets.
    • In cancer treatment: inhibits dihydrofolate reductase (DHFR), reducing synthesis of folate, which is involved in synthesis of the purine and pyramidine precursors required for DNA / RNA and cell proliferation.
    • Pharmacology

    • Serum half-life 8 hours
    • Renal excretion - caution in combination with NSAIDs

Clinical Use

    • Indications

    • Inflammatory diseases - refractory inflammatory bowel disease, rheumatoid arthritis, psoriasis
    • Chemotherapy - for certain cancers
    • Adverse Effects

    • Gastrointestinal - mouth ulcers, nausea / vomiting / abdominal pain
    • Hepatotoxicity - elevated LFTs, cirrhosis
    • Pulmonary - hypersensitivity pneumonitis
    • Bone marrow suppression - leukopaenia / thrombocytopaenia / anaemia
    • Monitoring

    • Monthly full blood count, renal function and LFTs.


The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.