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Gastro Drugs
 
 

Antiemetics

Gastric Secretion Modulators

Laxatives

Inflammatory Bowel Disease Medications

 
 

Anti-IL-12/23

 
 
  •  
    Subcut / IV
    Ustekinumab
    Stelara 

Overview

    • Mechanism of Action

    • A human monoclonal antibody directed against p40, a shared subunit present in both IL-12 and IL-23. Inhibition of IL-12 results in reduced differentiation of TH1 cells, while inhibition of IL-23 results in reduced induction of TH17 cells.

Clinical Use

    • Indications

    • Severe refractory Crohn’s disease
    • Refractory psoriatic arthritis
    • Moderate to severe plaque psoriasis
    • Adverse Effects

    • Injection site reactions
    • Upper respiratory tract infection
    • Dizziness
    • Headache
    • Nausea / vomiting / diarrhoea
    • Myalgias / arthralgias
    • Fatigue
 
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The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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