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Gastro Drugs
 
 

Antiemetics

Gastric Secretion Modulators

Laxatives

Inflammatory Bowel Disease Medications

 
 

Aminosalicylates

 
 
  •  
    Oral / Rectal
    Mesalazine
    Salofalk 
  •  
    Oral
    Sulfasalazine
    Salazopyrin 
     
    Not absorbed well – therefore most effective within the gut

Overview

    • Mechanism of Action

    • Inhibit 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, which results in increased adenosine release at the inflamed site. Adenosine binds to A2 receptors on inflammatory cells resulting in reduced inflammation.

Clinical Use

    • Indications

    • Acute episodes and maintenance of inflammatory bowel disease
    • Rheumatoid arthritis (sulfasalazine)
    • Seronegative arthritis (sulfasalazine) – reactive arthritis, psoriatic arthritis, anklyosing spondylitis
    • Adverse Effects

    • CNS - headache
    • Gastrointestinal - abdominal pain / nausea / vomiting / diarrhoea
    • Worsening of ulcerative colitis
    • Hepatotoxicity - elevated LFTs
 
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The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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