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Short-Acting Insulins

    Subcut / IV
    Insulin Aspart
    Subcut / IV
    Neutral Insulin
    Actrapid, Humulin R 
    Given 30 minutes before meals


  • In the context of hyperkalaemia, short-acting insulins such as novorapid and actrapid draw potassium ions into cells and can be used in conjunction with dextrose to acutely treat an elevated serum potassium.
    • Mechanism of Action

    • Insulin is an hormone normally produced by pancreatic beta cells that is responsible for regulation of glucose, fat and protein metabolism.
    • Effects

    • Glucose

    • Increased glycogen synthesis
    • Reduced hepatic glycogenolysis (glycogen breakdown)
    • Reduced hepatic gluconeogenesis (glucose formation)
    • Increased GLUT-4 mediated glucose uptake into adipose tissue and skeletal muscle
    • Fat

    • Increased triglyceride synthesis
    • Reduced lipolysis
    • Protein

    • Increased amino acid uptake
    • Reduced protein breakdown
    • Potassium

    • Increased cellular potassium uptake

Clinical Use

    • Indications

    • Severe hyperkalaemia
    • Glycaemic control for patients with type I or II diabetes
    • Contraindication

    • Hypoglycaemia.
    • Adverse Effects

    • Hypoglycaemia
    • Weight gain
    • Hypersensitivity reactions
Last updated on August 18th, 2018