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Magnesium Sulfate

    Oral / IV
    Magnesium Sulfate


    • Mechanism of Action

    • Normalises serum magnesium concentrations in the case of hypomagnesaemia.
      Magnesium is involved in many physiologic processes including cardiac Na⁺ / K⁺ ATPase, and hypomagnesaemia can result in depolarisation and torsades de pointes.
  • Also stimulates calcium delivery to the sarcoplasmic reticulum and competes with calcium for binding to troponin C, resulting in vasodilation and reduced contractility.

Clinical Use

    • Indications

    • Hypomagnesaemia
    • Severe acute asthma
    • Torsades de pointes
    • Ecclampsia
    • Adverse Effects

      Due to hypermagnesaemia:
    • Drowsiness
    • Muscle weakness / hyporeflexia
    • Vasodilation / hypotension
    • Blurred vision / diplopia
Last updated on August 18th, 2018