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Fluids
 
 
 

Aldosterone Antagonists

 
 
  •  
    Oral
    Spironolactone
    Aldactone, Spiractin 

Overview

    • Mechanism of Action

    • Inhibit the action of aldosterone on sodium-potassium exchange pumps in the distal convoluted tubule.
    • Pharmacology

    • Potassium-sparing diuretics.

Clinical Use

    • Indications

    • Refractory hypertension
    • Refractory heart failure
    • Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
    • Symptomatic ascites
    • Maintenance therapy for hypokalaemia
    • Primary aldosteronism
    • Hirsutism
    • Adverse Effects

    • Gynaecomastia
    • Nausea / vomiting / cramping / diarrhoea
    • Fatigue
    • Hyperkalaemia
Last updated on August 18th, 2018
 
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