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Endocrine Drugs

Very Short-Acting Insulins

    Subcut / IV
    Insulin Aspart
    Subcut / IV
    Insulin Lispro


  • Very short-acting insulins such as novorapid and humalog have a rapid onset and short duration, making them ideal for bolus dosing.
    • Mechanism of Action

    • Insulin is an hormone normally produced by pancreatic beta cells that is responsible for regulation of glucose, fat and protein metabolism.
    • Pharmacology

    • Onset 15 minutes
    • Peak effect 1-3 hours
    • Duration 3-5 hours

Clinical Use

    • Indications

    • Bolus dosing for type I or II diabetes
    • Insulin infusion for perioperative hyperglycaemic management
    • Insulin infusion for diabetic ketoacidosis
  • To be given 15 minutes before meals when given as bolus dosing.
    • Contraindication

    • Hypoglycaemia.
    • Adverse Effects

    • Hypoglycaemia
    • Weight gain
    • Hypersensitivity reactions
Last updated on January 1st, 2017


The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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