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Endocrine Drugs
 
 
 

GLP-1 Receptor Agonists

 
 
  •  
    Subcut
    Liraglutide
    Victoza 
  •  
    Subcut
    Exenatide
    Byetta (daily), Bydureon (weekly) 

Overview

    • Mechanism of Action

    • Directly agonise GLP-1 receptors, resulting in glucose-dependant insulin secretion.
  • The incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP), are released from the gastrointestinal tract. The incretins stimulate insulin secretion and inhibit glucagon secretion only under hyperglycaemic conditions, with additional effects of delayed gastric emptying, appetite suppression and weight loss.
  • These hormones normally have a short half-life as they are degraded by the enzyme dipeptidyl peptidase-4 (DPP-4).
    • Effects

    • Stimulation of insulin secretion in hyperglycaemia
    • Inhibition of glucagon secretion in hyperglucagonaemia
    • Slowed gastric emptying
    • Appetite suppression
    • Weight loss

Clinical Use

    • Indications

    • Glycaemic control for type II diabetics
    • Adjunctive therapy for weight loss
    • Adverse Effects

    • Hypoglycaemia
    • Headache
    • Reflux
    • Nausea / vomiting
    • Pancreatitis
Last updated on January 1st, 2017
 
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The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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