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Endocrine Drugs




    • Mechanism of Action

    • Synthetic 1,25-dihydroxy-vitamin D₃, which stimulates intestinal calcium / phosphate absorption and increased expression of RANK-ligand on osteoblast cell surfaces, resulting in a net increase in serum calcium and phosphate.
    • Pharmacology

    • Significantly more potent than cholecalciferol.

Clinical Use

    • Indications

    • Prevention and treatment of osteoporosis
    • Uraemic osteodystrophy
    • Hypoparathyroidism
    • Rickets
    • Hypocalcaemia
    • Adverse Effects

    • Hypercalcaemia
    • Headache
    • Nausea / abdominal pain
    • Rash
Last updated on January 1st, 2017


The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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