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Emergency Drugs
 
 
 

Protamine Sulfate

 
 
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    IV
    Protamine Sulfate

Overview

    • Mechanism of Action

    • Binds to and inactivates heparin.
    • Pharmacology

    • 1mg of protamine sulfate is expected to neutralize 100 units of heparin, though smaller doses should be given depending on time elapsed since heparin administration.

Clinical Use

    • Indications

    • Reversal of heparin-associated bleeding
    • Reversal of heparin preoperatively or after renal dialysis
    • Adverse Effects

    • Bradycardia
    • Hypotension
    • Dypnoea
    • Nausea / vomiting
Last updated on August 18th, 2018
 
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