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Emergency Drugs
 
 
 

Physostigmine

 
 
  •  
    IV / IM
    Physostigmine

Overview

    • Mechanism of Action

    • Inhibits acetylcholinesterase, resulting in reduced breakdown of acetylcholine which overcomes anticholinergic agents' competitive inhibition of nicotinic and muscarinic receptors.
    • Pharmacology

    • Crosses the blood-brain barrier, therefore able to counteract the central effects of anticholinergics.

Clinical Use

    • Indication

    • Anticholinergic toxicity, due to agents such as atropine, scopolamine or benztropine.
    • Adverse Effects

    • Nausea / vomiting
    • Salivation
    • Bradycardia
    • Convulsions
Last updated on August 18th, 2018
 
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