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Chemotherapy
 
 
 

Thymidylate Synthase Inhibitors

 
 
  •  
    IV
    5-Fluorouracil (5-FU)

  •  
    Oral
    Capecitabine
    Xeloda 
     
    Converted to 5-fluorouracil once absorbed orally

Overview

    • Mechanism of Action

    • Inhibit thymidylate synthase, resulting in reduced production of dTMP and reduced DNA synthesis.

Clinical Use

    • Indications

    • Certain solid organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects

    • Severe diarrhoea
    • Nausea / vomiting
    • Alopecia
    • Leucopaenia
Last updated on November 19th, 2019
 
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