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Antivirals
 
 
 
 
Antivirals
Antiviral agents are used to treat a variety of viral infections including herpesviruses, influenza and human immunodeficiency virus. This section outlines their mechanism of action, indications and potential adverse effects.
 

M2 Inhibitors

 
 
  •  
    Oral
    Amantadine
    Symmetrel 
  •  
    Oral
    Rimantadine
    Flumadine 

Overview

    • Mechanism of Action

    • Inhibit the ion channel function of M2 proteins on the viral membrane, preventing uncoating and disassembly of the virus once it enters cells.
    • Microbiology

    • Active against influenza A; no activity against influenza B.

Clinical Use

    • Indication

    • Influenza A prophylaxis.
    • Adverse Effects

    • Neuropsychiatric - dizziness, lethargy, ataxia, agitation, insomnia
    • Palpitations
    • Orthostatic hypotension
    • Dry mouth
    • Nausea / vomiting
    • Constipation
    • Livedo reticularis
Last updated on August 18th, 2018
 
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The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
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