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Antiviral Agents

Antiviral agents are used to treat a variety of viral infections including herpesviruses, influenza and human immunodeficiency virus. This section outlines their mechanism of action, indications and potential adverse effects.


The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
 Beutner KR, Friedman DJ, Forszpaniak C, Andersen PL, Wood MJ. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrobial Agents and Chemotherapy. 1995 Jul 1;39(7):1546-53. Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. The Lancet. 2015 May 2;385(9979):1729-37. Gnann JW, Barton NH, Whitley RJ. Acyclovir: mechanism of action, pharmacokinetics, safety and clinical applications. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 1983 Sep 10;3(5):275-83. Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson M, Spencer EA, Onakpoya I, Mahtani KR, Nunan DN, Howick J. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Sao Paulo Medical Journal. 2014;132(4):256-7. Muthuri SG, Venkatesan S, Myles PR, Leonardi-Bee J, Al Khuwaitir TS, Al Mamun A, Anovadiya AP, Azziz-Baumgartner E, Báez C, Bassetti M, Beovic B. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. The lancet Respiratory medicine. 2014 May 1;2(5):395-404. Rivas P, Morello J, Garrido C, Rodriguez-Novoa S, Soriano V. Role of atazanavir in the treatment of HIV infection. Ther Clin Risk Manag. 2009 Feb;5(1):99-116. Verjans GM, Boucher CA. Aciclovir for dual infection with HIV and HSV. The Lancet Infectious Diseases. 2012 Jun, 12(6): Pages 424-425.