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Antifungals

 
 
 
 

Triazoles

 
 
  •  
    Oral / IV
    Fluconazole
    Diflucan 
  •  
    Oral
    Itraconazole
    Cover against years and moulds
  •  
    Oral / IV
    Voriconazole
    Vfend 
     
    Activity against moulds, including Aspergillus
    • Mechanism of Action
    • Inhibit fungal synthesis of ergosterol, and element of the fungal cell membrane.
    • Microbiology
    • Effective against Cryptococcus and Candida. Voriconazole is also effective against moulds, including Aspergillus.

Clinical Use

    • Indications
    • Cryptococcal meningitis
    • Invasive candidiasis
    • Aspergillosis (voriconazole)
    • Adverse Effects
    • Rash
    • Nausea / vomiting / diarrhoea
 
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