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Antifungals

 
 
 
 

Polyenes

 
 
  •  
    IV
    Amphotericin B

  •  
    IV
    Liposomal Amphotericin B
    AmBisome 
     
    Lipid suspension results in binding directly to the fungal cell, resulting in low doses and significantly less toxicity
  •  
    IV
    Amphotericin B Lipid Complex
    Abelcet 
     
    Less toxicity due to direct fungal cell binding
    • Mechanism of Action
    • Bind to ergosterol on the cell membrane, resulting in the formation of pores, leakage of cytoplasmic components and cell death.
    • Microbiology
    • Effective against Candida, Cryptococcus and Aspergillus.

Clinical Use

    • Indications
    • Invasive candidiasis
    • Cryptococcal meningitis
    • Aspergillosis
    • Adverse Effects
    • Infusion reactions - fevers, rigors, arthralgias, hypotension, bronchospasm
    • Nephrotoxicity
    • Anaemia
 
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