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Antifungals

 
 
 
 

Echinocandins

 
 
  •  
    IV
    Caspofungin

  •  
    IV
    Anidulafungin
    Eraxis 
     
    No liver metabolism - can be used in patients with liver failure
    • Mechanism of Action
    • Inhibit synthesis of beta (1,3)-D-glucan, an essential component of the fungal / yeast cell wall.
    • Microbiology
    • Effective against invasive candidiasis and invasive aspergillosis.

Clinical Use

    • Indications
    • Febrile neutropaenia with suspected fungal source
    • Invasive candidiasis
    • Refractory invasive aspergillosis
    • Adverse Effects
    • Hypersensitivity reactions
    • Nausea / vomiting / diarrhoea
    • Headache
 
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