Login or Register to unlock everything MedSchool has to offer!
 
 
Antibacterials
 

Fluoroquinolones

 
 
  •  
    Oral / IV
    Ciprofloxacin
    Cipro 
  •  
    Oral
    Norfloxacin
    Noroxin 
  •  
    Oral / IV
    Moxifloxacin
    Avelox 
     
    Useful for pneumonia in patients with severe penicillin / cephalosporin allergy, due to Staph and atypical cover

Overview

    • Mechanism of Action

    • Inhibit DNA gyrase, preventing supercoiling of DNA and disrupting cell division.
    • Microbiology

    • Broad spectrum of activity against most gram negatives including Pseudomonas

Clinical Use

    • Indications

    • Gastroenteritis (empirical agents of choice)
    • Genitourinary infections - UTI, PID, bacterial prostatitis
    • Skin infections
    • Osteomyelitis / septic arthritis
    • Anthracosis
    • Adverse Effects

    • Nausea, vomiting, diarrhoea
    • Headache / dizziness / fatigue
    • QT prolongation
    • Tendinopathy (in children)
Last updated on August 11th, 2018
 
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
 

Read More...

The information in this section has been adapted in part from the Australian Therapeutic Goods Association website's repository of product information documents, which are available at https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI.
 Abu-Gharbieh E, Vasina V, Poluzzi E, De Ponti F. Antibacterial macrolides: a drug class with a complex pharmacological profile. Pharmacological research. 2004 Sep 30; 50(3): 211-22. Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. The Journal of antimicrobial chemotherapy. 2006;58:256-265. Bambeke FV. Glycopeptides in clinical development: pharmacological profile and clinical perspectives.Current Opinion in Pharmacology. 2004;4:471-478. Barza M, Scheife RT. Drug therapy reviews: Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics--part 4: aminoglycosides. American journal of hospital pharmacy. 1977;34:723. Bhattacharya S. The facts about penicillin allergy: a review. Journal of advanced pharmaceutical technology & research. 2010;1:11-17. Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of cephalosporins in penicillin-allergic patients: a literature review. The Journal of emergency medicine. 2012;42:612. Craig WA. The pharmacology of meropenem, a new carbapenem antibiotic. Clin Infect Dis. 1997; 24(S2): S266-75. Donowitz GR, Mandell GL. Beta-Lactam Antibiotics. N Engl J Med. 1988, 318: 419-426. Dryden MS. Linezolid pharmacokinetics and pharmacodynamics in clinical treatment. The Journal of antimicrobial chemotherapy. 2011;66 Suppl 4:iv7-iv15. Edwards DI. Mechanism of antimicrobial action of metronidazole. J Antimicrob Chemother. 1979 Sep, 5(5): 499-502. Frère JM. Mechanism of action of ?-lactam antibiotics at the molecular level. Biochemical Pharmacology. 1977 Dec, 26(23): 2203-2210. Gonzalez LSI, Spencer JP. Aminoglycosides: a practical review. American Family Physician [H.W. Wilson - GS]. 1998;58:1811. Kielhofner MA. Trimethoprim- Sulfamethoxazole: Pharmacokinetics, Clinical Uses, and Adverse Reactions. Texas Heart Institute Journal. 1990;17(2):86-93. Mazzei T, Mini E, Novelli A, Periti P. Chemistry and mode of action of macrolides. Journal of Antimicrobial Chemotherapy. 1993 Jan 1;31(suppl C):1-9. Müller M. Mode of action of metronidazole on anaerobic bacteria and protozoa. Surgery. 1983;93:165. Neu HC. Third generation cephalosporins: safety profiles after 10 years of clinical use. J Clin Pharmacol. 1990; 30(5): 396-403. Osono T, Umezawa H. Pharmacokinetics of macrolides, lincosamides and streptogramins. The Journal of antimicrobial chemotherapy. 1985;16 Suppl A:151. Reynolds PE, Somner EA. Comparison of the target sites and mechanisms of action of glycopeptide and lipoglycodepsipeptide antibiotics. Drugs under experimental and clinical research. 1990;16:385. Sahai J, Healy DP, Shelton MJ, Miller JS, Ruberg SJ, Polk R. Comparison of vancomycin- and teicoplanin-induced histamine release and “red man syndrome”. Antimicrobial Agents and Chemotherapy. 1990;34(5):765-769. Shinabarger DL, Marotti KR, Murray RW, et al. Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions.Antimicrobial Agents and Chemotherapy. 1997;41:2132-2136. Williams JD, Sefton AM. Comparison of macrolide antibiotics. J Antimicrob chemother. 1993; 31 (Suppl C): 11-26.
Feedback